Attenuation of inward rectifier potassium current contributes to the α1-adrenergic receptor-induced proarrhythmicity in the caval vein myocardium.

Alexandra D IvanovaTatiana S FilatovaDenis V AbramochkinAndrew AtkinsonHalina DobrzynskiZarema G KokaevaEkaterina M MerzlyakKsenia B PustovitVladislav S Kuzmin

Published in: Acta physiologica (Oxford, England) (2020)

Therefore, the reduced density of IK1 in rat SVC cardiomyocytes and sensitivity of this current to α1A-AR stimulation via PKC-dependent pathways might lead to proarrhythmic conduction in SVC myocardium by inducing RMP depolarization, AP prolongation, CV and dV/dtmax decrease.

Keyphrases

high glucose
drug induced
diabetic rats
oxidative stress
transcription factor
endothelial cells
vena cava
binding protein