Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions.

Ziwei LiuClancy Zhijian JiangAndrew D BondNicholas J ToscaJohn D Sutherland

Published in: Chemical communications (Cambridge, England) (2024)

Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5'-AMP as an analogue.

Keyphrases

signaling pathway
hydrogen peroxide
nucleic acid
protein kinase
room temperature
nitric oxide
high resolution