Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance.

Jessica M StringerSamuel C ForsterZhipeng QuLexie ProkopukMoira K O'BryanDavid K GardnerStefan J WhiteDavid AdelsonPatrick S Western

Published in: BMC biology (2018)

This study reveals a novel role for the histone-modifying complex, PRC2, in paternal intergenerational transmission of epigenetic effects on offspring, with important implications for understanding disease inheritance.

Keyphrases

dna methylation
mitochondrial dna
gene expression
high fat diet
dna repair
type diabetes
oxidative stress
skeletal muscle