Pd-Catalyzed Carboamination of Alkylidenecyclopropanes: Synthesis of Congested Pyrrolidines and Piperidines.
Phillip R LazzaraKeegan P FitzpatrickChad C EichmanPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2016)
The synthesis of densely functionalized N-heterocycles is an ongoing challenge in chemical synthesis. Herein, we report an efficient method for the construction of pyrrolidine and piperidine scaffolds using a palladium-catalyzed carboamination of alkylidenecyclopropanes.
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