Ursolic acid targets secreted phosphoprotein 1 to regulate Th17 cells against metabolic dysfunction-associated steatotic liver disease.

Yiyuan ZhengLina ZhaoZhekun XiongChaoyuan HuangQiuhong YongDan FangYugang FuSimin GuChong ChenJiacheng LiYingying ZhuJing LiuFengbin LiuYong Li

Published in: Clinical and molecular hepatology (2024)

Ursolic acid could improve immune inflammation in MASLD by modulating SPP1-mediated Th17 cell differentiation via the ERK signaling pathway, which is orchestrated jointly by ITGB1 and CD44, emerging as a linchpin in this molecular cascade.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
oxidative stress
cell cycle arrest
epithelial mesenchymal transition
cell proliferation
endoplasmic reticulum stress
single molecule