Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorption associated with LPS-induced periodontal disease in vivo.
Morgana Rodrigues Guimarães StabiliMarcell Costa de MedeirosDanuza RossiAngelo Constantino CamilliCleslei Fernando ZanelliSandro Roberto ValentiniLuis Carlos SpolidorioKeith Lough KirkwoodCarlos RossaPublished in: Clinical oral investigations (2020)
The results suggest that site-specific inhibition of MMP-13 may be an interesting strategy to modulate inflammation and reduce bone resorption in osteolytic inflammatory diseases.