Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16.

Nicholas P CaseyKatrin KleinmannsChristopher ForcadosPascal F GelebartSandy JoaquinaMartine LodeEmmanuelle BenardFatemeh KavehBenjamin CaulierChristiane Helgestad GjerdeElvira García de JalónDavid J WarrenKristina LindemannErik RokkonesBen DavidsonMarit Renee MyhreGunnar KvalheimLine BjørgeEmmet McCormackElse Marit InderbergSébastien Wälchli

Published in: Journal for immunotherapy of cancer (2024)

Our in vitro and in vivo results, including PDX studies, demonstrate that the CA125 domain of MUC16 represents an excellent target for treating MUC16-positive malignancies.

Keyphrases

single cell
protein kinase
cancer therapy
stem cells
case control
mesenchymal stem cells
bone marrow