Myelin-specific T cells in animals with Japanese macaque encephalomyelitis.

Aparna N GovindanKristin S FitzpatrickMinsha ManoharanIan TaggeSteven G KohamaBetsy FergusonSamuel M PetersonGrayson S WongWilliam D RooneyByung ParkMichael K AxthelmDennis N BourdetteLarry S ShermanScott W Wong

Published in: Annals of clinical and translational neurology (2021)

JME possesses an immune-mediated component that involves both CD4+ and CD8+ T cells specific for myelin antigens. JME may shed new light on inflammatory demyelinating disease pathogenesis linked to gamma-herpesvirus infection.

Keyphrases

white matter
oxidative stress
dendritic cells
multiple sclerosis
nk cells