Metabolic Syndrome and Risk of Amyotrophic Lateral Sclerosis: Insights from a Large-Scale Prospective Study.

Junwei ZhangWen CaoJiali XieChunyang PangLingfei GaoLuyi ZhuYaojia LiHuan YuLihuai DuDongsheng FanBin-Bin Deng

Published in: Annals of neurology (2024)

MetS exhibits a robust association with an increased susceptibility to ALS, particularly in individuals with a lower BMI. Furthermore, metabolites and metabolomics, as potential mediators, provide invaluable insights into the intricate biological mechanisms. ANN NEUROL 2024.

Keyphrases

amyotrophic lateral sclerosis
metabolic syndrome
body mass index
mass spectrometry
ms ms
insulin resistance
uric acid
neural network
cardiovascular risk factors
adipose tissue
skeletal muscle