Synthesis of and Metal Complexation with a Chiral Cyclam.

Tetraazamacrocycles, like cyclam 1, are well-studied polyamine ligands for metal ions that were first developed to model biological processes. Despite being studied for nearly 60 years, the development of chiral variants of 1 has been limited. We report the synthesis of a chiral variant of 1, the tetraazamacrocycle 2. Outlined herein are the synthesis of 2, a preliminary study of its complexation with metal ions, and the properties of the resulting metal complexes.