Single-cell sequencing reveals VEGFR as a potential target for CAR-T cell therapy in chordoma.

Huantong WuXinqiang LiBoyan ZhangPenghao LiuMaoyang QiYueqi DuCan ZhangWanru DuanZan Chen

Published in: British journal of cancer (2024)

This study provides a comprehensive single-cell landscape of human chordoma and highlights its heterogeneity and the role played by TGF-β in chordoma progression. Our findings substantiate the potential of VEGFR as a target for CAR-T cell therapies in chordoma which, together with modulated TGF-β signalling, may augment the efficacy of CAR-T cells.

Keyphrases

single cell
cell therapy
rna seq
high throughput
transforming growth factor
endothelial cells
stem cells
vascular endothelial growth factor
mesenchymal stem cells
human health
risk assessment
bone marrow