Role of 23.4 Gy upfront whole-brain radiation therapy following high-dose methotrexate for primary central nervous system lymphoma: a comparative analysis of whole-brain radiation therapy versus no radiation therapy.
Nalee KimDo Hoon LimSang Eun YoonSeok Jin KimWon Seog KimPublished in: Journal of neuro-oncology (2021)
Upfront RT with a reduced dose of 23.4 Gy, showed favorable outcomes in patients with stable disease or progressive disease after initial HD-MTX. In addition, upfront RT appears to be an effective treatment for PCNSL when rituximab or stem cell transplantation is not feasible.
Keyphrases
- high dose
- radiation therapy
- stem cell transplantation
- low dose
- diffuse large b cell lymphoma
- resting state
- radiation induced
- white matter
- locally advanced
- multiple sclerosis
- functional connectivity
- cerebral ischemia
- squamous cell carcinoma
- type diabetes
- replacement therapy
- cerebrospinal fluid
- adipose tissue
- brain injury
- hodgkin lymphoma
- metabolic syndrome
- combination therapy