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Cu-Catalyzed Desulfonylative Amination of Benzhydryl Sulfones.

Masakazu NamboYasuyo TaharaJacky C-H YimCathleen M Crudden
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
A new method for the synthesis of benzhydryl amines from the reaction of readily available sulfone derivatives with amines is described. The Cu-catalyzed desulfonylative amination not only provides structurally diverse benzhydryl amines in good yields, but is also applicable to iterative and intramolecular aminations. Control experiments suggested that the formation of a Cu-carbene intermediate generated from the sulfone substrate, which represents a new route for desulfonylative transformations.
Keyphrases
  • room temperature
  • aqueous solution
  • metal organic framework
  • computed tomography
  • amino acid