Cu-Catalyzed Desulfonylative Amination of Benzhydryl Sulfones.
Masakazu NamboYasuyo TaharaJacky C-H YimCathleen M CruddenPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
A new method for the synthesis of benzhydryl amines from the reaction of readily available sulfone derivatives with amines is described. The Cu-catalyzed desulfonylative amination not only provides structurally diverse benzhydryl amines in good yields, but is also applicable to iterative and intramolecular aminations. Control experiments suggested that the formation of a Cu-carbene intermediate generated from the sulfone substrate, which represents a new route for desulfonylative transformations.