Plasma Biomarkers of Brain Injury and Their Association With Brain MRI and Cognition in Type 1 Diabetes.

Amy B KargerIlya M NasrallahBarbara H Braffett José A LuchsingerChristopher M RyanIonut BebuValerie ArendsMohamad HabesRose A Gubitosi-Klug Naomi S Chaytor Geert Jan BiesselsAlan M Jacobsonnull null

Published in: Diabetes care (2024)

In this aging T1D cohort, biomarkers of brain injury did not demonstrate an AD-like profile. NfL emerged as a biomarker of interest in T1D because of its association with higher HbA1c, accelerated brain aging on MRI, and cognitive dysfunction. Our study suggests that early neurodegeneration in adults with T1D is likely due to non-AD/nonamyloid mechanisms.

Keyphrases

brain injury
cerebral ischemia
subarachnoid hemorrhage
white matter
type diabetes
contrast enhanced
magnetic resonance imaging
resting state
diffusion weighted imaging
computed tomography
mild cognitive impairment
insulin resistance
glycemic control
adipose tissue
skeletal muscle
blood brain barrier
weight loss