Evaluating whole-brain tissue-property changes in MRI-negative pharmacoresistant focal epilepsies using MR fingerprinting.
Ting-Yu SuYingying TangJoon Yul ChoiSiyuan HuKen SakaieHiroatsu MurakamiStephen JonesIngmar BluemckeImad M NajmDan MaZhong Irene WangPublished in: Epilepsia (2022)
MRF revealed group-level T1 increase in limbic/paralimbic structures ipsilateral to the epileptic origin, in patients with pharmacoresistant focal epilepsy and no apparent lesions on MRI, suggesting that these regions may be commonly affected by seizures in the epileptic brain. The significant association between T1 increase and higher seizure burden may reflect progressive tissue damage.
Keyphrases
- contrast enhanced
- diffusion weighted imaging
- magnetic resonance imaging
- resting state
- white matter
- temporal lobe epilepsy
- multiple sclerosis
- magnetic resonance
- computed tomography
- functional connectivity
- cerebral ischemia
- oxidative stress
- high resolution
- single cell
- risk factors
- blood brain barrier
- brain injury
- subarachnoid hemorrhage