ROS-driven cellular methane formation: Potential implications for health sciences.
Frank KepplerLeonard ErnstDaniela PolagJingyao ZhangMihaly BorosPublished in: Clinical and translational medicine (2022)
Recently it has been proposed that methane might be produced by all living organisms via a mechanism driven by reactive oxygen species that arise through the metabolic activity of cells. Here, we summarise details of this novel reaction pathway and discuss its potential significance for clinical and health sciences. In particular, we highlight the role of oxidative stress in cellular methane formation. As several recent studies also demonstrated the anti-inflammatory potential for exogenous methane-based approaches in mammalians, this article addresses the intriguing question if ROS-driven methane formation has a general physiological role and associated diagnostic potential.
Keyphrases
- anaerobic digestion
- reactive oxygen species
- oxidative stress
- carbon dioxide
- healthcare
- public health
- induced apoptosis
- human health
- dna damage
- cell death
- mental health
- anti inflammatory
- health information
- cell cycle arrest
- health promotion
- signaling pathway
- cell proliferation
- social media
- multidrug resistant
- gram negative
- heat shock