Oxaliplatin-induced haematological toxicity and splenomegaly in mice.

Justin G Lees Daniel WhiteBrooke A KeatingMallory E Barkl-LukePreet G S MakkerDavid GoldsteinGila Moalem-Taylor

Published in: PloS one (2020)

Chronic oxaliplatin treatment dose dependently induced haematological toxicity and splenomegaly characterised by numerous physiological and morphological changes, which occurred independently of sinusoidal obstructive syndrome.

Keyphrases

high glucose
diabetic rats
oxidative stress
drug induced
endothelial cells
case report
metabolic syndrome
high fat diet induced
insulin resistance
skeletal muscle