TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells.
Parisa Vahidi FerdowsiKiran Deep Kaur AhujaJeffrey M BeckettStephen MyersPublished in: Cells (2021)
Our data show that capsaicin-mediated stimulation of TRPV1 in differentiated C2C12 cells leads to activation of CAMKK2 and AMPK, and increased glucose oxidation which is concomitant with an elevation in intracellular ATP level. Further studies of the effect of TRPV1 channel activation by capsaicin on glucose metabolism could provide novel therapeutic utility for the management of IR and T2DM.
Keyphrases
- skeletal muscle
- induced apoptosis
- cell cycle arrest
- type diabetes
- neuropathic pain
- hydrogen peroxide
- blood glucose
- endoplasmic reticulum stress
- oxidative stress
- cell death
- machine learning
- nitric oxide
- signaling pathway
- metabolic syndrome
- big data
- adipose tissue
- weight loss
- protein kinase
- artificial intelligence
- data analysis