Crosstalk between IL-15Rα + tumor-associated macrophages and breast cancer cells reduces CD8 + T cell recruitment.

Wenlong ZhangQing ZhangNanfei YangQian ShiHuifang SuTingsheng LinZhonglei HeWenxin WangHongqian GuoPing-Ping Shen

Published in: Cancer communications (London, England) (2022)

The IL-15Rc-HIF-1α-CX3CL1 signaling pathway serves as a crosstalk between macrophages and tumor cells in the tumor microenvironment of breast cancer. Targeting this pathway may provide a potential therapeutic strategy for enhancing the efficacy of cancer immunotherapy.

Keyphrases

breast cancer cells
signaling pathway
epithelial mesenchymal transition
cancer therapy
endothelial cells
oxidative stress
cell proliferation
drug delivery
childhood cancer