O-GlcNAcylation is essential for therapeutic mitochondrial transplantation.

Ji Hyun ParkMasayoshi TanakaTakafumi NakanoEster LicastroYoshihiko NakamuraWenlu LiElga EspositoEmiri T MandevilleSherry Hsiang-Yi ChouMingMing NingEng H Lo Kazuhide Hayakawa

Published in: Communications medicine (2023)

These findings suggest that AGE-modification in extracellular mitochondria may induce danger signals, but O-GlcNAcylation can prevent glycation and improve the therapeutic efficacy of transplanted mitochondria in the CNS.

Keyphrases

cell death
endoplasmic reticulum
reactive oxygen species
oxidative stress
blood brain barrier
cell therapy
bone marrow