A barcode of multilocus nuclear DNA identifies genetic relatedness in pre- and post-Artemether/Lumefantrine treated Plasmodium falciparum in Nigeria.

Kolapo Muyiwa OyebolaOluwagbemiga Olanrewaju AinaEmmanuel Taiwo IdowuYetunde Adeola OlukosiOlusola Sunday AjibayeOlubunmi Adetoro OtubanjoTaiwo Samson AwololaGordon Akanzuwine AwandareAlfred Amambua-Ngwa

Published in: BMC infectious diseases (2018)

Persistence of DNA-detectable parasitaemia in more than 18% of cases after treatment and indications of genetic relatedness between pre- and post-treatment infections warrants further investigation of a larger population for signs of reduced ACT efficacy in Nigeria.

Keyphrases

plasmodium falciparum
genome wide
circulating tumor
cell free
single molecule
copy number
dna methylation
nucleic acid
gene expression
circulating tumor cells
replacement therapy