Genetic analysis of a morphologically heterogeneous ovarian endometrioid carcinoma.

Felipe C GeyerFresia ParejaKathleen A BurkeAnne M SchultheisYaser R HusseinJiqing YeMaria R De FilippoCaterina MarchioGabriel S MacedoSalvatore PiscuoglioRaymond S LimEugene ToyRajmohan MuraliAchim A JungbluthJorge Sergio Reis-FilhoRobert A SoslowBritta Weigelt

Published in: Histopathology (2017)

Histologically distinct components of ovarian endometrioid carcinomas may show intratumour genetic heterogeneity but be clonally related, harbouring a complex clonal composition. In the present case, SMARCA4 mutations were probably early events, whereas TP53 somatic mutations were acquired later in evolution.

Keyphrases

endometrial cancer
copy number
clear cell
single cell
genome wide
high grade
gene expression
dna methylation