Dimethyl Fumarate Exerts a Neuroprotective Effect by Enhancing Mitophagy via the NRF2/BNIP3/PINK1 Axis in the MPP + Iodide-Induced Parkinson's Disease Mice Model.
Poojitha PinjalaKamatham Pushpa TryphenaAmrita KulkarniPrince Giri GoswamiDharmendra Kumar KhatriPublished in: Journal of Alzheimer's disease reports (2024)
DMF confers neuroprotection by activating the BNIP3/PINK1/Parkin pathway, enhancing the autophagosome formation via LC3, and improving mitophagy in PD models, and could be a potential therapeutic option in PD.
Keyphrases
- cerebral ischemia
- nlrp inflammasome
- oxidative stress
- diabetic rats
- high glucose
- signaling pathway
- brain injury
- high fat diet induced
- simultaneous determination
- type diabetes
- adipose tissue
- blood brain barrier
- high resolution
- metabolic syndrome
- liquid chromatography
- wild type
- solid phase extraction
- high resolution mass spectrometry
- stress induced