Reference Susceptibility Testing and Genomic Surveillance of Clostridioides difficile, United States, 2012-17.

Amy S GargisMaria KarlssonAshley L PaulickKaren F AndersonMichelle AdamczykNicholas VlachosAlyssa G KentGillian A McAllisterSusannah L McKayAlison L HalpinValerie AlbrechtDavina CampbellLauren KorhonenChristopher A ElkinsJ Kamile RasheedAlice Y GuhL Clifford McDonaldJoseph D Lutgringnull null

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

Elevated MICs to antibiotics used for treatment of C. difficile infection were rare and there was no increase in MICs over time. The lack of vanA/B genes or mutations consistently associated with elevated vancomycin MICs suggests there are multifactorial mechanisms of resistance. Ongoing surveillance of C. difficile using reference AST and WGS to monitor MIC trends and the presence of antibiotic resistance mechanisms is essential.

Keyphrases

clostridium difficile
public health
genome wide
methicillin resistant staphylococcus aureus
copy number
gene expression
combination therapy
replacement therapy