Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?

Azyadeh Camacho-OrdonezAmin Cervantes-ArriagaMayela Rodríguez-ViolanteAna Jimena Hernandez-MedranoSelma Alin Somilleda-VenturaHector J Pérez-CanoAngel Nava-CastañedaOscar Guerrero-Berger

Published in: European journal of ophthalmology (2023)

Total αSyn reflex tear levels were increased in subjects with PD compared to controls. PD patients showed significant thinning of the inner retinal layers and thickening of outer retinal layers in comparison with controls. Total αSyn levels positively correlate with the central volume of the inner nuclear layer in PD. The combination of these biomarkers might have a possible role as a diagnostic tool in PD subjects.

Keyphrases

optical coherence tomography
diabetic retinopathy
end stage renal disease
optic nerve
newly diagnosed
chronic kidney disease
ejection fraction
prognostic factors
peritoneal dialysis
patient reported outcomes
patient reported
rotator cuff