Urethral dysfunction and therapeutic effects of a PDE 5 inhibitor (tadalafil) in a rat model of detrusor underactivity induced by pelvic nerve crush injury.

Ei-Ichiro Takaoka Masahiro KurobeTakahisa SuzukiNobutaka ShimizuJoonbeom KwonHiroki OkadaNaoki Yoshimura Christopher J Chermansky

Published in: Neurourology and urodynamics (2020)

PNC rats revealed both DU and impaired urethral relaxation. PDE 5 inhibition in PNC rats enhanced urethral relaxation during voiding, resulting in improved voiding efficiency. Thus, urethral dysfunction could be a potential target for the treatment of inefficient voiding associated with neurogenic DU.

Keyphrases

urinary incontinence
oxidative stress
spinal cord injury
single molecule
rectal cancer
single cell
botulinum toxin
peripheral nerve
lower urinary tract symptoms