Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury.

Leyuan XuDiana SharkeyLloyd G Cantley

Published in: Journal of the American Society of Nephrology : JASN (2019)

GM-CSF-induced MCP-1/CCR2 signaling plays an important role in the cross-talk between injured tubular cells and infiltrating immune cells and myofibroblasts, and promotes sustained inflammation and tubular injury with progressive interstitial fibrosis in the late stages of U-IRI.

Keyphrases

high glucose
oxidative stress
ischemia reperfusion injury
induced apoptosis
endothelial cells
diabetic rats
dendritic cells
regulatory t cells
multiple sclerosis
cell cycle arrest
liver fibrosis
endoplasmic reticulum stress
signaling pathway
cell death
cell proliferation