Synthesis, Characterization and Biodistribution of GdF 3 :Tb 3+ @RB Nanocomposites.
Oleg E PolozhentsevIlia A PankinDarya V KhodakovaPavel V MedvedevAnna S GoncharovaAleksey Yu MaksimovOleg I KitAlexander V SoldatovPublished in: Materials (Basel, Switzerland) (2022)
Herein we report the development of a nanocomposite for X-ray-induced photodynamic therapy (X-PDT) and computed tomography (CT) based on PEG-capped GdF 3 :Tb 3+ scintillating nanoparticles conjugated with Rose Bengal photosensitizer via electrostatic interactions. Scintillating GdF 3 :Tb 3+ nanoparticles were synthesized by a facile and cost-effective wet chemical precipitation method. All synthesized nanoparticles had an elongated "spindle-like" clustered morphology with an orthorhombic structure. The structure, particle size, and morphology were determined by transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS) analysis. The presence of a polyethylene glycol (PEG) coating and Rose Bengal conjugates was proved by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG), and ultraviolet-visible (UV-vis) analysis. Upon X-ray irradiation of the colloidal PEG-capped GdF 3 :Tb 3+ -Rose Bengal nanocomposite solution, an efficient fluorescent resonant energy transfer between scintillating nanoparticles and Rose Bengal was detected. The biodistribution of the synthesized nanoparticles in mice after intravenous administration was studied by in vivo CT imaging.
Keyphrases
- photodynamic therapy
- dual energy
- computed tomography
- electron microscopy
- quantum dots
- high resolution
- mycobacterium tuberculosis
- energy transfer
- reduced graphene oxide
- drug delivery
- magnetic resonance imaging
- positron emission tomography
- radiation therapy
- type diabetes
- contrast enhanced
- magnetic resonance
- gold nanoparticles
- highly efficient
- high glucose
- carbon nanotubes
- molecular dynamics simulations
- cancer therapy
- solid state
- tandem mass spectrometry