Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis.
Maryam Mehdipour DalivandParastou TizroJulie PartainAnita AggarwalJack LichyFrancisco Mot AraVictor E NavaPublished in: Case reports in hematology (2022)
Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterization revealed an unusual MPL (T487I) point mutation and unmutated VH4-39. After nonstandard chemotherapy, the patient remains in morphologic remission. These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms.
Keyphrases
- african american
- acute lymphoblastic leukemia
- locally advanced
- case report
- liver failure
- multiple myeloma
- acute myeloid leukemia
- diffuse large b cell lymphoma
- high grade
- respiratory failure
- allogeneic hematopoietic stem cell transplantation
- bone marrow
- rectal cancer
- drug induced
- disease activity
- single cell
- squamous cell carcinoma
- radiation therapy
- rheumatoid arthritis
- systemic lupus erythematosus
- hepatitis b virus
- intensive care unit
- chemotherapy induced
- acute respiratory distress syndrome