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The antinociceptive and anti-alpha-glucosidase effects of glucosides from Hemiphragma heterophyllum Wall.

Chun-Fang WenYu-Xiao LiKe-Xin NieQiu HeYa LuZi-Liang WangXi-Shan BaiYan-Hong LiXiang-Zhong Huang
Published in: Natural product research (2024)
Hemiphragma heterophyllum Wall. is commonly used in traditional Yi herbal medicine for treating bellyache and toothache. In the current study, an unreported monoterpene glucoside, ( S )-thymoquinol O -(6- O -oleuropeoyl)- β -d-glucopyranoside ( 1 ), together with 11 known glucosides were obtained from the whole herb of H. heterophyllum . Their structures were determined based on a detailed analysis of spectroscopic data and acid hydrolysis and methanolysis reactions. Bioassay results showed that compounds 1 and 10 at 40 mg/kg exhibited significant antinociceptive activity in the acetic acid-induced writhing model, with inhibitions of 59.80% and 64.07%, respectively. Moreover, five of the isolates showed moderate anti- α -glucosidase activities with IC 50 values ranging from 5.67 to 46.16 μM.
Keyphrases
  • molecular docking
  • anti inflammatory
  • electronic health record
  • high resolution
  • molecular dynamics simulations
  • high intensity
  • machine learning