Perivascular clusters of Th2 cells and M2 macrophages in allergic contact dermatitis to methylchloroisothiazolinone and methylisothiazolinone.

Anangélica R VirgensHeliana Freitas de Oliveira GoesGabriel C de CarvalhoAnna Julia PietrobonAnna Cláudia C C BrancoYasmim A L RamosNaiura V PereiraRaquel L OrfaliValéria AokiLuiz Fernando F da SilvaMirian N SottoVitor M S Dos ReisMaria Notomi Sato

Published in: Experimental dermatology (2021)

M2 macrophages and Th2 cells participate in the immunopathogenesis of MCI/MI ACD. Dermal dendrocytes and M2 macrophages may assist the formation of CD4+ T cells perivascular clusters. These findings render a mechanistic insight into the MCI/MI reaction. Further analysis at different timepoints of patch testing is required to fully comprehend this ACD kinetics.

Keyphrases

induced apoptosis
cell cycle arrest
mild cognitive impairment
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell death
cell proliferation