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Perivascular clusters of Th2 cells and M2 macrophages in allergic contact dermatitis to methylchloroisothiazolinone and methylisothiazolinone.

Anangélica R VirgensHeliana Freitas de Oliveira GoesGabriel C de CarvalhoAnna Julia PietrobonAnna Cláudia C C BrancoYasmim A L RamosNaiura V PereiraRaquel L OrfaliValéria AokiLuiz Fernando F da SilvaMirian N SottoVitor M S Dos ReisMaria Notomi Sato
Published in: Experimental dermatology (2021)
M2 macrophages and Th2 cells participate in the immunopathogenesis of MCI/MI ACD. Dermal dendrocytes and M2 macrophages may assist the formation of CD4+ T cells perivascular clusters. These findings render a mechanistic insight into the MCI/MI reaction. Further analysis at different timepoints of patch testing is required to fully comprehend this ACD kinetics.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • mild cognitive impairment
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • cell death
  • cell proliferation