Telomere length and Wnt/β-catenin pathway in adamantinomatous craniopharyngiomas.
Jose Italo Soares MotaRui Milton Patrício Silva-JúniorClarissa Silva MartinsAna Carolina BuenoLuiz Eduardo WildembergXimene Lima da Silva AntunesJorge Guilherme Okanobo OzakiFernanda Borchers Coeli-LacchiniCarlos Garcia-PeralAntonio Edson Rocha OliveiraAntônio Carlos SantosAyrton Custodio MoreiraHelio Rubens MachadoMarcelo Volpon Dos SantosLeandro M ColliMonica R GadelhaSonir Roberto Rauber AntoniniMargaret de CastroPublished in: European journal of endocrinology (2022)
mutations are more frequent in children and adolescents and appear to associate with progressive disease. CTNNB1-mutated aCPs have shorter telomeres, demonstrating a relationship between the Wnt/β-catenin pathway and telomere biology in the pathogenesis of aCPs.