Identification of the Transcription Factor Relationships Associated with Androgen Deprivation Therapy Response and Metastatic Progression in Prostate Cancer.
Nitya V SharmaKathryn L PellegriniVeronique OuelletFelipe O GiusteSelvi RamalingamKenneth WatanabeEloise Adam-GrangerLucresse FossouoSungyong YouMichael R FreemanPaula VertinoKaren ConneelyAdeboye O OsunkoyaDominique TrudelAnne-Marie Mes-MassonJohn A PetrosFred SaadCarlos S MorenoPublished in: Cancers (2018)
We have identified TFCGs associated with pronounced initial transcriptional response to ADT, aggressive signatures, and metastasis. Our findings suggest multiple new hypotheses that could lead to novel combination therapies to prevent the development of CRPC following ADT.
Keyphrases
- transcription factor
- prostate cancer
- radical prostatectomy
- squamous cell carcinoma
- small cell lung cancer
- dna binding
- gene expression
- genome wide
- genome wide identification
- bioinformatics analysis
- dna methylation
- oxidative stress
- bone marrow
- heat shock
- mesenchymal stem cells
- cell therapy
- replacement therapy
- heat stress