Mitochondrial apurinic/apyrimidinic endonuclease 1 enhances mtDNA repair contributing to cell proliferation and mitochondrial integrity in early stages of hepatocellular carcinoma.

Veronica BazzaniArianna BarchiesiDorota RadeckaRiccardo PravisaniAntonio GuadagnoCarla Di LoretoUmberto BaccaraniCarlo Vascotto

Published in: BMC cancer (2020)

Our study confirms the prominent role of the mitochondrial form of APE1 in the early stages of HCC development and the relevance of the non-nuclear fraction of APE1 in the disease progression. We have also confirmed overexpression of Mia40 and the role of the MIA pathway in the APE1 import process. Based on our data, inhibition of the APE1 transport by blocking the MIA pathway could represent a new therapeutic approach for reducing mitochondrial metabolism by preventing the efficient repair of mtDNA.

Keyphrases

oxidative stress
cell proliferation
copy number
gene expression
transcription factor
dna damage
big data
dna repair
dna methylation
pi k akt
deep learning
genome wide