Hyperglycaemia is inversely correlated with live M. bovis BCG-specific CD4+ T cell responses in Tanzanian adults with latent or active tuberculosis.

Noémie Boillat-BlancoAnneth-Mwasi N TumboMatthieu PerreauPatrizia AmelioKaushik L RamaiyaMaliwaza MgangaChristian SchindlerSebastien GagneuxKlaus ReitherNicole Probst-HenschGiuseppe PantaleoClaudia DaubenbergerDamien Portevin

Published in: Immunity, inflammation and disease (2018)

These results support the hypothesis that hyperglycaemia negatively impacts antigen processing and/or presentation of whole mycobacteria delaying secretion of key cytokines involved in TB immunity.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
hiv aids
emergency department