Opsoclonus myoclonus ataxia syndrome, ovarian teratoma and anti-NMDAR antibody: an 'unresolved' mystery.
Angel T MiraclinArun Mathai ManiAjith SivadasanAditya NairMunagapati ChristinaAbigail Ruth GojerSharon MiltonJohn A Jude PrakashRohit N BenjaminPrabhakar Appaswamy ThirumalVivek MathewSanjith AaronPublished in: BMJ neurology open (2023)
With coexistent neuropsychiatric manifestations, OMAS can be considered a distinct entity of autoimmune encephalitis, pathogenesis being immune activation against known/unknown neuronal cell surface antigens. The observation of absence of anti-NMDAR antibody in patients with teratoma-associated OMAS and vice versa is intriguing. Further research on the potential role of ovarian teratoma in evoking neuronal autoimmunity and its targets is required. The management challenge in both cases including the potential use of BOR has been highlighted.