Application of Venn's diagram in the diagnosis of pleural tuberculosis using IFN-γ, IP-10 and adenosine deaminase.

Ana Paula SantosRaquel da Silva CorrêaMarcelo Ribeiro-AlvesAna Carolina Oliveira Soares da SilvaThiago Thomaz MafortJanaína LeungGeraldo Moura Batista PereiraLuciana Silva RodriguesRogério Rufino

Published in: PloS one (2018)

IFN-γ, IP-10, and ADA in PlTB effusions are significantly higher than in non-PlTB cases. IFN-γ is an excellent rule-in and rule-out test compared to IP-10 and ADA. The combination of IFN-γ and ADA, in a reviewed cut-off point, showed to be particularly useful to clinicians as their positive results combined prompts immediate treatment for TB while both negative results suggest further investigation.

Keyphrases

dendritic cells
immune response
mycobacterium tuberculosis
palliative care
pulmonary tuberculosis
combination therapy
hiv aids
human immunodeficiency virus
electronic health record