Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study.

John Abel EnghThor UelandIngrid AgartzDimitrios AndreouPål AukrustBirgitte BoyeErlend BøenOle Kristian DrangeTorbjørn ElvsåshagenSigrun HopeMargrethe Collier HøeghInge JoaErik JohnsenRune Andreas KrokenTrine Vik LagerbergTove LekvaUlrik Fredrik MaltIngrid MelleGunnar MorkenTerje NærlandVidar Martin SteenKirsten Wedervang-ResellMelissa Auten WeibellLars Tjelta WestlyeSrdjan DjurovicNils Eiel SteenOle Andreas Andreassen

Published in: Schizophrenia bulletin (2021)

These results show aberrant levels of BAFF and APRIL and association with psychotic symptoms in patients with SCZ and BIP. This suggest that dysregulation of the TNF system, mediated by BAFF and APRIL, is involved in the pathophysiology of psychotic disorders.

Keyphrases

bipolar disorder
major depressive disorder
signaling pathway
rheumatoid arthritis
sleep quality
endoplasmic reticulum