Galectin-3 favours tumour metastasis via the activation of β-catenin signalling in hepatocellular carcinoma.

Mengjia SongQiuzhong PanJieying YangJunyi HeJianxiong ZengShaoyan ChengYue HuangZi-Qi ZhouQian ZhuChaopin YangYulong HanYan TangHao ChenDe-Sheng WengJian-Chuan Xia

Published in: British journal of cancer (2020)

The Galectin-3-β-catenin-IGFBP3/vimentin signalling cascade was determined as a central mechanism controlling HCC metastasis, providing possible biomarkers for predicating vascular metastasis and sorafenib resistance, as well as potential therapeutic targets for the treatment of HCC patients.

Keyphrases

epithelial mesenchymal transition
end stage renal disease
cell proliferation
newly diagnosed
risk assessment
combination therapy
human health