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Does anti-HPA-1a affect birthweight in fetal and neonatal alloimmune thrombocytopenia?

Margaret McKelvySrishti TyagiEmilie Vander HaarMadhavi LakkarajaTim TomyStacy CorkeThea PalmerAmihai RottenstreichRick KapurHuiying ZhiDebra NewmanNina Schatz-SiemersJames B Bussel
Published in: Pediatric blood & cancer (2024)
Untreated FNAIT-affected newborns were not small; however, treatment of FNAIT-affected pregnancies increased newborn birthweights despite corrections to account for other factors that might have influenced the results. High dose IVIG is believed to "block" FcRn and lower maternal anti-HPA-1a levels, and thus increase birthweights by reducing levels of maternal anti-HPA-1a and reducing placental villitis.
Keyphrases
  • gestational age
  • high dose
  • birth weight
  • pregnancy outcomes
  • pregnant women
  • low dose
  • body mass index
  • low birth weight
  • cord blood
  • combination therapy