Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis.
Abrar AhmadLee-Ling LimMario Luca MorieriClaudia Ha-Ting TamFeifei ChengTinashe ChikoworeMonika Dudenhöffer-PfeiferHugo FitipaldiChuiguo HuangSarah KanbourSudipa SarkarRobert Wilhelm KoivulaAyesha A MotalaSok Cin TyeGechang YuYingchai ZhangMichele ProvenzanoDiana SherifaliRussell J de SouzaDeirdre Kay Tobiasnull nullMaria F GomezRonald C W MaNestoras Nicolas MathioudakisPublished in: Communications medicine (2024)
Despite high interest in this topic, very few studies conducted rigorous analyses to demonstrate incremental predictive utility beyond established CVD risk factors for T2D. The most promising markers identified were NT-proBNP, TnT, TyG and GRS-CHD, with the highest strength of evidence for NT-proBNP. Further research is needed to determine their clinical utility in risk stratification and management of CVD in T2D.