Population pharmacokinetics of sublingually administered tacrolimus in infants and young children with liver transplantation.

Natalia Riva Manuel IbarraZinnia P Parra-GuillenMaria Eugenia GalvánErika PérezGuido Trezeguet RenattiPaulo Cáceres GuidoClarisa LopezNieves LicciardoneEsteban HalacMarcelo DipAlejandro CruzOscar ImventarzaDaniel BuamschaIñaki F TroconizPaula S Schaiquevich

Published in: British journal of clinical pharmacology (2022)

A population pharmacokinetic model of sublingually administered tacrolimus in paediatric patients was developed to characterize different absorption mechanisms. Once the model is externally validated, the effect of post-transplant time on clearance and the sedation status may be considered in routine dosing management.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
emergency department
intensive care unit
peritoneal dialysis
clinical practice
mechanical ventilation