Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis: A Matter of Inflammation.

Eileen MoritzGabriele JedlitschkyJosefine NegnalMladen V TzvetkovGünter DaumMarcus DörrStephan B FelixHenry VölzkeMatthias NauckEdzard SchwedhelmPeter MeiselThomas KocherBernhard H RauchBirte Holtfreter

Published in: Journal of inflammation research (2021)

We report an intriguingly significant association of various periodontal parameters with serum levels of the inflammatory lipid mediator S1P. Our data point towards a key role of S1P during periodontitis pathology. Modulation of local S1P levels or its signaling properties may represent a potential future therapeutic strategy to prevent or to retard periodontitis progression and possibly reduce periodontitis-related tooth loss.

Keyphrases

oxidative stress
electronic health record
risk assessment
deep learning
machine learning
human health
artificial intelligence
data analysis