CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment.
Michele LauriolaGrazia D'OnofrioAnnamaria la TorreFilomena CicconeCarmela GermanoLeandro CascavillaAntonio GrecoPublished in: Biomedicines (2022)
Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients were evaluated with cognitive, neuropsychiatric, affective, and functional assessment scales. MTA was evaluated from 0 (no atrophy) to 4 (severe atrophy). The homocysteine serum was set to two levels: between 0 and 10 µmol/L, and >10 µmol/L. The cholesterol and glycemia blood concentrations were measured. Hypertension and atrial fibrillation presence/absence were collected. A total of 14 patients were MTA 0, 44 patients were MTA 1, 63 patients were MTA 2, 79 patients were MTA 3, and 39 patients were MTA 4. Cognitive ( p < 0.0001) and functional ( p < 0.0001) parameters decreased according to the MTA severity. According to the diagnosis distribution, AD patient percentages increased by MTA severity ( p < 0.0001). In addition, the homocysteine levels increased according to MTA severity ( p < 0.0001). Depression ( p < 0.0001) and anxiety ( p = 0.001) increased according to MTA severity. This study encourages and supports the potential role of MTA score and CT scan in the field of neurodegenerative disorder research and diagnosis.
Keyphrases
- end stage renal disease
- computed tomography
- newly diagnosed
- chronic kidney disease
- atrial fibrillation
- prognostic factors
- peritoneal dialysis
- heart failure
- cognitive impairment
- magnetic resonance imaging
- positron emission tomography
- multiple sclerosis
- patient reported outcomes
- acute coronary syndrome
- early onset
- sleep quality
- climate change
- percutaneous coronary intervention
- human health
- left atrial
- drug induced