Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake.
Jeronimo Nunes RuganiCélia Maria Ferreira GontijoFrédéric FrézardRodrigo Pedro SoaresRubens Lima do Monte-NetoPublished in: Memorias do Instituto Oswaldo Cruz (2019)
There is a clear correlation between ARM56/58 upregulation and Sb resistance in AT-harbouring patients, suggesting the use of these markers as potential indicators to help the treatment choice and outcome, preventing therapeutic failure.