Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake.

Jeronimo Nunes RuganiCélia Maria Ferreira GontijoFrédéric FrézardRodrigo Pedro SoaresRubens Lima do Monte-Neto

Published in: Memorias do Instituto Oswaldo Cruz (2019)

There is a clear correlation between ARM56/58 upregulation and Sb resistance in AT-harbouring patients, suggesting the use of these markers as potential indicators to help the treatment choice and outcome, preventing therapeutic failure.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
cell proliferation
emergency department
patient reported outcomes
adverse drug
long non coding rna
patient reported
human health