DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.

Gilles GasparoniSebastian BultmannPavlo LutsikTheo F J KrausSabrina SordonJulia VlcekVanessa DietingerMartina SteinmaurerMelanie HaiderChristopher B MulhollandThomas ArzbergerSigrun RoeberMatthias RiemenschneiderHans A KretzschmarArmin GieseHeinrich LeonhardtJörn Walter

Published in: Epigenetics & chromatin (2018)

Our data highlight the complex interplay between disease, age and cell-type-specific methylation changes in AD risk genes thus offering new perspectives for the validation and interpretation of large EWAS results.

Keyphrases

dna methylation
genome wide
endothelial cells
gene expression
spinal cord
electronic health record
big data
cognitive decline
machine learning
induced pluripotent stem cells
spinal cord injury
copy number
transcription factor
mild cognitive impairment