An NIF-doped ZIF-8 hybrid membrane for continuous antimicrobial treatment.

Sodium alginate (ALG) composites with ZIF-8 and niflumic acid (NIF) were prepared by a one-pot method at room temperature and characterized by FTIR, SEM and XRD studies. In the composite, ZIF-8 was used as a highly connected node in a supercrosslinked polymer network. In addition, the material exhibits good antibacterial activity against Staphylococcus aureus and Escherichia coli in vitro . Compared to the original ALG membrane and ZIF-8, the ZIF-NIF-ALG membrane has the following advantages: stronger antibacterial properties; slow release of Zn(ii); high drug loading; and longer sustained release time. This research introduces new concepts for the design and manufacture of various antimicrobial membranes and broadens the range of applications of MOFs.