Effect of Serum Urate Lowering With Allopurinol on Blood Pressure in Young Adults: A Randomized, Controlled, Crossover Trial.
Angelo Lino GaffoDavid A CalhounElizabeth J RahnSuzanne OparilPeng LiTanja DudenbostelDaniel I FeigDavid T ReddenPaul MuntnerPhillip J FosterStephanie R Biggers-ClarkAmy MudanoSebastian Eduardo SattuiMichael B SaddekniS Louis BridgesKenneth G SaagPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Our findings indicate that urate-lowering therapy with allopurinol does not lower systolic BP or hsCRP level in young adults when compared with placebo, despite improvements in FMD. These findings do not support urate lowering as a treatment for hypertension in young adults.