Flucloxacillin decreases tacrolimus blood trough levels: a single-center retrospective cohort study.

Herman Veenhof Hugo M Schouw Martine T P Besouw Daniel J Touw Valentina Gracchi

Published in: European journal of clinical pharmacology (2020)

Flucloxacillin decreases tacrolimus trough levels, possibly through a CYP3A4 and/or P-gp-inducing effect. It is strongly recommended to closely monitor tacrolimus and everolimus trough levels during flucloxacillin treatment and up to 2 weeks after discontinuation of flucloxacillin.

Keyphrases

preterm birth