Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration.

Joery GoossensMaria BjerkeSara Van MosseveldeTobi Van den BosscheJohan GoemanBart De VilAnne SiebenJean-Jacques MartinPatrick CrasPeter Paul De DeynChristine Van BroeckhovenJulie van der ZeeSebastiaan Engelborghs

Published in: Alzheimer's research & therapy (2018)

There is an added value for Nf-L in the differential diagnosis of FTLD. Progranulin levels in CSF depend on mutation status, and GRN mutation carriers seem to be affected by more severe neurodegeneration.

Keyphrases

cerebrospinal fluid
signaling pathway
oxidative stress
early onset
pi k akt
nuclear factor